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  In people who have the disease, pieces of a sticky protein found in the fatty membrane surrounding nerve cells -- called beta-amyloid -- break off and clump together to form the plaques. Some clumps may block signaling between nerve cells or activate immune system responses that further damage cells. These brain changes usually spread as the disease progresses, and plaques may form in regions of the brain involved in processes like learning, memory, thinking and planning early on in the disease.  
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  "A while ago there was an excess of exuberance and nowperhaps an excess of pessimism," Brazil's central bank chief, Alexandre Tombini, said in a statement prepared for delivery toa meeting of finance officials on Saturday.  
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